Claussnitzer Lab
Seeking to understand how genetic variants impact Type 2 diabetes
The Claussnitzer lab is devoted to developing experimental and computational frameworks to accelerate and pre-empt V2F studies using human primary and immortalized adipocytes as model systems. We are enthusiastic about adding function to genome-wide association study results (Variant-to-Function, V2F studies). Our focus is on how to systematically dissect the mechanisms by which these variants affect human disease.
Who We Are
Our researchers are a unique, collaborative community of post-docs and professional staff scientists based at the Broad Institute and our partner institutions.
Understanding the biological consequences of genetic associations
Genetic associations hold enormous promise for medicine but are rarely traced to the causal genetic target genes and mechanism of action (Variant-to-Function, V2F studies). Our inability to understand the biological consequences of these associations is the primary barrier to translating GWAS discoveries into actionable biological and therapeutic hypotheses. My research program integrates both wet-lab and computational approaches to link individual genetic risk loci to their function (individual locus V2F studies), and to systematically link global genetic variation to their underlying mechanisms of action (Scalable V2F studies).
